In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL.Chemdraw full crack Đang rất được mọi người quan tâm và chú ý đến mongchienthan.vn Là kênh chuyên chia sẻ về bản tin của game, công nghệ, cũng như chia sẻ các thủ thuật tiện ích hữu ích cho người dùng.
In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. IC50 Value: 0.1 pM Target: microtubule In vitro: Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. IC50 Value: 0.1 pM Target: microtubule in vitro: Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. N-debenzoyl-(3'-RS)-taxol + benzoyl-CoA -> taxol + coenzyme A + H+ PlantCyc CPD-8718 from the stem bark of Taxus brevifolia and Taxus cuspidata (Taxaceae) Zerenex MolecularĪDCs cytotoxin Microtubule/Tubulin MedChem Express HY-B0015Īntibody-drug conjugates/ADCs Related MedChem Express HY-B0015Īntibody-drug conjugates/ADCs Related Cell Cycle/DNA Damage MedChem Express HY-B0015 Name 'taxol' is now limited, as Taxol is a registered trade mark. It is a mitotic inhibitor used in cancer chemotherapy. ChEBI CHEBI:45863Ī tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. Note that the use of the formĮr generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Toxicity: IPR-RAT LD50 33 mg kg-1, IPR-MUS LD50 128 mg kg-1 OU Chemical Safety Data (No longer updated) More details.
Incompatible with strong oxidizing agents. Appearance: white crystalline powder OU Chemical Safety Data (No longer updated) More details.Experimental Solubility: 10 mM in H2O MedChem Express HY-B0015.Experimental Boiling Point: 957.1 ☌ Cayman Chemical (old) CM110346.Experimental Melting Point: 213-216 ☌ OU Chemical Safety Data (No longer updated) More detailsĢ14.5 ☌ Jean-Claude Bradley Open Melting Point Dataset 14775, 16370Ģ16.5 ☌ Jean-Claude Bradley Open Melting Point Dataset 28375Ģ13 ☌ (Decomposes) Matrix Scientific 096914Ģ13 ☌ (Decomposes) Sigma-Aldrich USP-1491332.Experimental Physico-chemical Properties.